Despite the considerable evolution on bone tissue engineering strategies, currently used bone-related implants have a limited lifespan in the body and some still exhibit failure in function due to lack of osteointegration.
A new focus on tissue regeneration has been the development of biomaterials that can elicit specific biological responses at implantation. It is well established that modifying the surface topography of a biomaterial has a positive effect on regeneration.
The research presented in this talk focus on different techniques to develop surface topography on hard bioceramics in order to improve the biological response to these materials.
The interaction of cells and bacteria with microfabricated surfaces and the modulation of cells behaviour and differentiation pathways through topographical stimuli will be addressed

Ângela Carvalho graduated in Biomedical Engineering at the School of Management and Industrial Studies (ESEIG) of the Porto Polytechnic (IPP) in 2009. She pursued her Master Degree in Biomedical Engineering at the Faculty of Engineering of the University of Porto (FEUP), and started her research activities at INEB. She later pursued her PhD and was awarded a grant from FCT for her project: Microfabricated surfaces for guided tissue regeneration.

During her PhD she was a visiting researcher at the Institute of Ceramics and Glass (ICV-CSIC, Spain), the Nanotech West Laboratory (The Ohio State University, USA) and the Institute of Electronics of the Bulgarian Academy of Sciences (Bulgaria).

Currently, her research focus on the development of microfluidic platforms with microstructured surfaces for detection and isolation of cancer circulating biomarkers.